{"_asset":{"@search.score":9.205937,"Name":"Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger","AlternateTitleCommaDelimited":"","Id":"9353","AssetLocationUri":null,"Abstract":"

Hospitalisation and routine antibiotic treatment are recommended for children with complicated severe acute malnutrition (SAM) but this may exacerbate antimicrobial resistance. Here, we investigate carriage of Gram-negative bacteria in children under five years of age receiving treatment for SAM in Niger, comparing the frequency of colonisation with bacteria carrying resistance genes at admission, during hospital stay and at discharge. E. coli isolates carrying a bla_NDM-5 gene were selected for whole-genome sequencing. Rectal colonisation with bacteria carrying ß-lactamase genes is high, with 76% (n = 1042/1371) of children harbouring bacteria carrying a bla_CTXM-1-group gene and 25% (n = 338/1371) carrying a bla_NDM-5 gene. Over two-thirds of children who did not carry bacteria with a carbapenemase gene at admission are colonised with bacteria carrying a carbapenemase gene at discharge (n = 503/729, 69%). E. coli ST167 carrying bla_NDM-5 gene is recovered from 11% (n = 144/1371) of children. Here we highlight infection control and bacterial AMR transmission concerns amongst a vulnerable population in need of medical treatment.

","PublicationOrPresentationDate":"2025-08-01T00:00:00Z","LastModifiedDate":"2025-08-19T20:25:06.404Z","IsDeleted":false,"DigitalObjectIdentifier":"10.1038/s41467-025-61718-w","ContentTypeName":"Research","ParentContentTypeName":"Journal Article","JournalName":"Nature Communications","ContentType":"Journal Article > Research","AvailabilityTypeId":1,"AvailabilityType":"Full Text","JournalIssue":"1","JournalVolume":"16","JournalPages":"","JournalAbbreviation":"Nat Commun","Conference":null,"ConferenceStartDate":null,"ConferenceEndDate":null,"content":null,"UrlSlug":"acquisition-escherichia-coli-carrying-extended-spectrum-ß-lactamase-carbapenemase-genes-hospitalised-children-severe-acute-malnutrition-niger","collections":[],"countries":[{"Name":"Niger","Id":159}],"asset_languages":[{"AlternateTitle":"","language":[{"Id":1,"Name":"English"}],"contentTranslation":[],"contentLocation":[]}],"creators":[{"Name":"Li M","Id":13182,"ac":[{"Order":7}]},{"Name":"Isanaka S","Id":17038,"ac":[{"Order":12}]},{"Name":"Langendorf C","Id":17133,"ac":[{"Order":16}]},{"Name":"Kanapathipillai R","Id":20293,"ac":[{"Order":13}]},{"Name":"Mambula C","Id":21099,"ac":[{"Order":14}]},{"Name":"Mouniaman I","Id":25301,"ac":[{"Order":15}]},{"Name":"Hassan B","Id":36989,"ac":[{"Order":3}]},{"Name":"Sands K","Id":37248,"ac":[{"Order":0}]},{"Name":"Lankapalli AK","Id":37249,"ac":[{"Order":1}]},{"Name":"Lai G","Id":37250,"ac":[{"Order":2}]},{"Name":"Portal EA","Id":37251,"ac":[{"Order":4}]},{"Name":"Mathias JA","Id":37252,"ac":[{"Order":5}]},{"Name":"Boostrom I","Id":37253,"ac":[{"Order":6}]},{"Name":"Cook K","Id":37254,"ac":[{"Order":8}]},{"Name":"Premchand-Branker S","Id":37255,"ac":[{"Order":9}]},{"Name":"Jones LS","Id":37256,"ac":[{"Order":10}]},{"Name":"Sayinzonga-Makombe N","Id":37257,"ac":[{"Order":11}]},{"Name":"Walsh TR","Id":37258,"ac":[{"Order":17}]},{"Name":"Spiller OB","Id":37259,"ac":[{"Order":18}]}],"keywords":[{"Name":"antibiotic resistance","Id":1},{"Name":"pediatrics","Id":20},{"Name":"genetics & genomics","Id":29},{"Name":"malnutrition","Id":33},{"Name":"severe acute malnutrition","Id":71},{"Name":"antimicrobial resistance","Id":72}]}}

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Acquisition of Escherichia coli carrying extended-spectrum ß-lactamase and carbapenemase genes by hospitalised children with severe acute malnutrition in Niger