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Showing 1 - 20 of 38 Items
Showing 1 - 20 of 38 Items
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Research

Diagnostic performance and kinetics of hepatitis E viral RNA and IgM antibody test positivity in a genotype 1 outbreak in South Sudan

Koyuncu A, Nesbitt R, Alvarez C, Asilaza KV, Wamala J,  et al.
2025-08-14 • Journal of Infectious Diseases
2025-08-14 • Journal of Infectious Diseases

BACKGROUND

Diagnostics are essential for understanding hepatitis E epidemiology, but the field performanc...

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The genetic diversity of Nipah virus across spatial scales

Cortes-Azuero O, Lefrancq N, Nikolay B, McKee C, Cappelle J,  et al.
2024-12-16 • Journal of Infectious Diseases
2024-12-16 • Journal of Infectious Diseases

BACKGROUND

Nipah virus (NiV), a highly lethal virus in humans, circulates in Pteropus bats throughout South and Southeast Asia. Difficulty in obtaining viral genomes from bats m...

Disease-specific differences in pharmacokinetics of paromomycin and miltefosine between post-kala-azar dermal leishmaniasis and visceral leishmaniasis patients in eastern Africa

Chu WY, Verrest L, Younis BM, Musa AM, Mbui J,  et al.
2024-12-16 • Journal of Infectious Diseases
2024-12-16 • Journal of Infectious Diseases

Treatment regimens for post-kala-azar dermal leishmaniasis (PKDL) are usually extrapolated from those for visceral leishmaniasis (VL), but drug pharmacokinetics (PK) can differ due to...

Perspectives on advancing countermeasures for Filovirus disease: Report from a multi-sector meeting

Sprecher A, Cross RW, Marzi A, Martins KA, Wolfe D,  et al.
2023-08-19 • Journal of Infectious Diseases
2023-08-19 • Journal of Infectious Diseases
Although there are now approved treatments and vaccines for Ebola virus disease (EVD), the case fatality of EVD remains unacceptably high even when treated with the newly approved therap...

Ebola Virus Disease in pregnancy: clinical, histopathologic and Immunohistochemical findings

Muehlenbachs A, de la Rosa Vazquez O, Bausch DG, Schafer IJ, Paddock C,  et al.
2016-05-25 • Journal of Infectious Diseases
2016-05-25 • Journal of Infectious Diseases
Here we describe clinicopathologic features of EVD in pregnancy. One woman infected with Sudan virus in Gulu, Uganda in 2000 had a stillbirth and survived, and another woman with Bundibu...

Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II)

Schmid C, Richer M, Bilenge CM, Josenando T, Chappuis F,  et al.
2005-06-01 • Journal of Infectious Diseases
2005-06-01 • Journal of Infectious Diseases
BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy ...

Clinical chemistry of patients with Ebola in Monrovia, Liberia

de Wit E, Kramer S, Prescott JB, Rosenke K, Falzarano D,  et al.
2016-07-28 • Journal of Infectious Diseases
2016-07-28 • Journal of Infectious Diseases
The development of point-of-care clinical chemistry analyzers has enabled the implementation of these ancillary tests in field laboratories in resource-limited outbreak areas. The Eterna...

Effects of Treatment Interruption Patterns on Treatment Success Among Patients With Multidrug-Resistant Tuberculosis in Armenia and Abkhazia

Bastard M, Sanchez-Padilla E, Hewison CCH, Hayrapetyan A, Khurkhumal S,  et al.
2014-10-13 • Journal of Infectious Diseases
2014-10-13 • Journal of Infectious Diseases
The success of the current treatment regimen for multidrug-resistant tuberculosis (MDR-TB) is poor partly due to a high defaulter rate. Many studies explored predictors of poor outcomes,...

Environmental contamination and persistence of Ebola virus RNA in an Ebola treatment center

Poliquin PG, Vogt F, Kasztura M, Leung A, Deschambault Y,  et al.
2016-06-30 • Journal of Infectious Diseases
2016-06-30 • Journal of Infectious Diseases
BACKGROUND
Ebola viruses (EBOVs) are primarily transmitted by contact with infected body fluids. Ebola treatment centers (ETCs) contain areas that are exposed to body fluids through ...

The contribution of Ebola viral load at admission and other patient characteristics to mortality in a Médecins Sans Frontières (MSF) Ebola Case Management Centre (CMC), Kailahun, Sierra Leone, June -October, 2014

Fitzpatrick G, Vogt F, Gbabai O, Decroo T, Keane M,  et al.
2015-05-22 • Journal of Infectious Diseases
2015-05-22 • Journal of Infectious Diseases
This paper describes patient characteristics, including Ebola viral load, associated with mortality in an MSF Ebola case management centre. Out of 780 admissions between June and October...

Comparative Effectiveness of Interventions to Improve the HIV Continuum of Care and HIV Preexposure Prophylaxis in Kenya: A Model-Based Analysis

Luong Nguyen LB, Freedberg KA, Wanjala S, Maman D, Szumilin E,  et al.
2020-10-27 • Journal of Infectious Diseases
2020-10-27 • Journal of Infectious Diseases
Background
In Western Kenya up to one-quarter of the adult population was human immunodeficiency virus (HIV)-infected in 2012. The Ministry of Health, Médecins Sans Frontières, and ...

Modeling of EBV Infection and Antibody Responses in Kenyan Infants with Different Levels of Malaria Exposure Shows Maternal Antibody Decay is a Major Determinant of Early EBV Infection

Reynaldi A, Schlub TE, Piriou E, Ogolla S, Sumba OP,  et al.
2016-08-28 • Journal of Infectious Diseases
2016-08-28 • Journal of Infectious Diseases
The combination of Epstein-Barr virus (EBV) infection and high malaria exposure are risk factors for endemic Burkitt lymphoma, and evidence suggests that infants in regions of high malar...

The kynurenine pathway of tryptophan catabolism, CD4+ T-cell recovery, and mortality among HIV-infected Ugandans initiating antiretroviral therapy

Byakwaga H, Huang Y, Muzoora C, Kembabazi A, Weiser SD,  et al.
2014-02-28 • Journal of Infectious Diseases
2014-02-28 • Journal of Infectious Diseases
Human immunodeficiency virus (HIV) infection-induced indoleamine 2,3-dioxygenase-1 (IDO) expression in activated monocytes and dendritic cells catabolizes tryptophan to kynurenine and ot...

A long-lasting measles epidemic in Maroua, Cameroon 2008-2009: mass vaccination as response to the epidemic

Luquero FJ, Pham-Orsetti H, Cummings DAT, Ngaunji PE, Nimpa M,  et al.
2011-07-01 • Journal of Infectious Diseases
2011-07-01 • Journal of Infectious Diseases
A measles outbreak occurred in Maroua, Cameroon, from January 2008 to April 2009. In accordance with recent World Health Organization guidelines, an outbreak-response immunization (ORI) ...

Marburg hemorrhagic fever in Durba and Watsa, Democratic Republic of the Congo: clinical documentation, features of illness, and treatment

Colebunders R, Tshomba A, Van Kerkhove MD, Bausch DG, Campbell P,  et al.
2007-11-15 • Journal of Infectious Diseases
2007-11-15 • Journal of Infectious Diseases
The objective of the present study was to describe day of onset and duration of symptoms of Marburg hemorrhagic fever (MHF), to summarize the treatments applied, and to assess the qualit...

More Challenges From Ebola: Infection of the Central Nervous System

Wong G, Qiu X, Bi Y, Formenty P, Sprecher A,  et al.
2016-10-15 • Journal of Infectious Diseases
2016-10-15 • Journal of Infectious Diseases
Cases of relapsed Ebola virus disease involving symptoms in the central nervous system are reminiscent of our past observations with some nonhuman primates (NHPs) that survived acute Ebo...

2017 outbreak of Ebola Virus Disease in Northern Democratic Republic of Congo

Nsio JM, Kapteshi K, Makiala S, Raymond F, Tshapenda G,  et al.
2019-04-03 • Journal of Infectious Diseases
2019-04-03 • Journal of Infectious Diseases
BACKGROUND
In 2017, the Democratic Republic of the Congo (DRC) recorded its eighth Ebola virus disease (EVD) outbreak, approximately 3 years after the previous outbreak.

MET...

Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites

Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JH,  et al.
2007-04-01 • Journal of Infectious Diseases
2007-04-01 • Journal of Infectious Diseases
BACKGROUND: Relapses originating from hypnozoites are characteristic of Plasmodium vivax infections. Thus, reappearance of parasitemia after treatment can result from relapse, recrudesce...

Should outbreak response immunization be recommended for measles outbreaks in middle- and low-income countries? An update

Cairns KL, Perry RT, Ryman TK, Nandy R, Grais RF
2011-07-01 • Journal of Infectious Diseases
2011-07-01 • Journal of Infectious Diseases
Measles caused mortality in >164,000 children in 2008, with most deaths occurring during outbreaks. Nonetheless, the impact and desirability of conducting measles outbreak response immun...

The value of and challenges for cholera vaccines in Africa

von Seidlein L, Jiddawi MS, Grais RF, Luquero FJ, Lucas M,  et al.
2013-11-01 • Journal of Infectious Diseases
2013-11-01 • Journal of Infectious Diseases
The 21st century saw a shift in the cholera burden from Asia to Africa. The risk factors for cholera outbreaks in Africa are incompletely understood, and the traditional emphasis on prov...